It's time for Week 3 of the GameSided NFL Simulation presented by Madden 25, and th..."/> It's time for Week 3 of the GameSided NFL Simulation presented by Madden 25, and th..."/>
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Madden 25 Week 3 NFL Simulation

By Michael Straw

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Indianapolis Colts @ San Francisco 49ers

When Colin Kaepernick is on his game, the 49ers are near impossible to beat.

Kaepernick ran and passed all over the Colts to lead San Francisco to a convincing win a week after failing to score a touchdown against Seattle. Kaepernick finished with 325 yards passing and 113 yards rushing. He was responsible for all four San Francisco touchdown, rushing for one and passing for three.

Andrew Luck was a non-factor for the Colts in this one as he left the game midway through the first quarter with a concussion. Backup Matt Hasselbeck threw for 253 yards and two touchdowns which were both caught by Reggie Wayne.

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