It's the second week of the NFL season which means it's time for the second we..."/> It's the second week of the NFL season which means it's time for the second we..."/>
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Madden 25 Week 2 NFL Simulation

By Michael Straw

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Carolina Panthers @ Buffalo Bills

After both teams lost their Week 1 games after having late leads, the Panthers and Bills squared off with each team look for its first win.

Despite a 14-point second quarter, the Panthers just looked like a team that didn’t belong on an NFL field in this blowout victory by the Bills.

Rookie QB E.J. Manuel, who was solid in his first start against New England, finished the game with 236 passing yards and three touchdowns.

Running back C.J. Spiller ran for 137 yards and a score; Fred Jackson had 74 yards rushing and two touchdowns.

Panthers QB Cam Newton finished 11-26 for 103 yards, a touchdown, and three interceptions.

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