It's Week 4 of the Gamesided Madden 25 weekly simulation, and for the first time th..."/> It's Week 4 of the Gamesided Madden 25 weekly simulation, and for the first time th..."/>
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Madden 25 Week 4 NFL Simulation

By Michael Straw

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San Francisco 49ers @ St. Louis Rams

This week’s slate of games start with an NFC West matchup between San Francisco and St. Louis in the dome.  Both teams are coming off tough losses and sit at 1-2 on the season behind division-leading Seattle.

It was a tight game throughout, as most divisional games are, and it took a late touchdown pass from Colin Kaepernick to Kyle Williams with just 1:15 left to give the 49ers the win. Kaepernick finished the game with 236 yards passing and one touchdown.

Rams running back Darryl Richardson racked up 144 yards and a touchdown on 23 carries.

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